Journal: Viruses
Article Title: 3-Chymotrypsin-like Protease (3CLpro) of SARS-CoV-2: Validation as a Molecular Target, Proposal of a Novel Catalytic Mechanism, and Inhibitors in Preclinical and Clinical Trials
doi: 10.3390/v16060844
Figure Lengend Snippet: 3CLpro inhibitors in preclinical and clinical trials. The table provides an overview of 3CLpro inhibitors in preclinical and clinical trials. Each row represents a specific molecule under investigation, with information about the 3CLpro inhibitors’ name, the pharmaceutical company responsible for their development, the route of administration, the current state of development, the inhibitory concentration (IC 50 ) in nanomolar for 3CLpro inhibitors in preclinical trials, the effective concentration (EC 50 ) in micromolar for 3CLpro inhibitors in preclinical or clinical trials, and the unique identifier (ID) of the registered clinical trial. These data offer a comprehensive perspective on 3CLpro inhibitors in the research and development phase for potential use in treating COVID-19.
Article Snippet: XiannuoxinTM: Simnotrelvir (SIM0417) and Ritonavir (SSD8432) , Simcere , Oral , Phase II/III , 9 , 34 , NCT05373433 [ ] .
Techniques: Clinical Proteomics, Concentration Assay